Diabetes and Obesity International Journal (DOIJ) - Medwin Publishers

Chronic diseases are stimulated in the womb through adaptations acquired by the fetus in response to malnutrition. Maternal malnutrition during early pregnancy, in relation to low birth weight as well as uterine growth restriction, may adversely influence offspring metabolism and health. Parental nutritional imbalance, either through global nutritional manipulation or deficiencies in specific nutrients, predisposes the offspring to metabolic disease. Exposure to environmental factors in early life can influence the developmental process as well as long-term health in humans. The famine affected fertility, weight gain during pregnancy, maternal blood pressure, infant size at birth and development of the central nervous system, are associated with an increased risk of adult-onset metabolic syndrome. The point to ponder over here is how these risk factors interact at the cellular level so as to cause disease? Here, epigenetic epidemiology enables researchers to explore critical links bet...

Now, a day’s obesity is a common health issue; it is a grave and persistent disease that can have a depressing effect on our body. Flabby and fatness might be raising the danger of many physical conditions, like heart disease, diabetes osteoarthritis and cancers. In the present days it is approximate more than 300 million overweight people international. Obesity is related to the disorder of lipid metabolism and the enzymes involved in the process of lipid metabolism. So, the lipid metabolism is the main target for the development of anti-obesity drugs. On the other hand, most of the anti-obesity drugs now introvert due to severe adverse effects. That’s why; the naturopathic management for obesity has been extensively recommended from primordial times and attains impact in the current circumstances also. Conventional therapeutic foliage and their dynamicphyto constituents have been used for the handling of fatness and problems derived from obesity. This review mainly emphasis on natur...

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Abstract Introduction: Liraglutide is an effective drug for the treatment of type 2 diabetes mellitus (T2DM). Liraglutide 3 mg is approved for obesity. We assessed the effect of liraglutide on body weight and tolerability in obese individuals with lesser dose. Objective: To evaluate the effect of the liraglutide on weight loss in overweight and obese Indian patients. Material and methods: Data was collected from 15 patients over 12 month duration from case record section retrospectively. Patient’s weight and dose of liraglutide were studied. Result: Mean weight at baseline was 101.68 kg, minimum dose of liraglutide at the beginning was 0.3 mg .The mean change in body weight after 1 year was 13.39 kg and maximum dose of liraglutide was 2.4 mg. The most common side effect was nausea. Conclusion: Liraglutide treatment, at a much lower dose than 3 mg daily, significantly improves weight loss in obese non diabetic Indian subjects. Reema Tandale Kashiva, explained neatly about Weight...